NK Cell-priming Inert Tumor Cells

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** An off-the-shelf (OTS) preparation of replication-incompetent tumor cells derived from a human tumor cell line (INB16 cells) that are able to prime and activate endogenous natural killer (NK) cells in vivo, with potential immunomodulating and antineoplastic activities. Upon intravenous administration, NK cell-priming inert tumor cells, which express multiple, essential priming signals, bind to the patient's own resting NK cells, thereby priming and activating these NK cells. The tumor-primed NK (tpNK) cells or tumor-killing memory-like NK cells are then able to recognize and lyse tumor cells, including a variety of NK-resistant tumor cells. Activating ligands are often missing from resistant tumor cells.

**Synonyms:** - INKmune (TM) - Immune Priming Cells - Natural Killer Cell-priming Inert Tumor Cells