NOVA Family

**Semantic type:** Amino Acid, Peptide, or Protein

**Definition:** Expressed in brain (neurons or astrocytes), NOVA Family Genes encode NOVA Family nuclear proteins (NOVA1, NOVA2), autoantigens in POMA recognized by IgG ANNA-2 that contain 3 KH domains and may regulate RNA splicing in neurons and astrocytes. NOVA proteins form structural complexes with other proteins. Found as one or multiple copies of a conserved 70-aa motif in diverse nucleic acid binding, and other, proteins, the KH domain binds RNA; each motif appears necessary for binding. (NCI)