KMT2A/FOXO3 Fusion Gene

**Semantic type:** Gene or Genome

**Definition:** A fusion gene that results from a chromosomal translocation t(6;11)(q21;q23) that fuses exon 1 to 7, 8, or 11 of the KMT2A gene upstream of exon 2 of the FOXO3 gene. This chromosomal rearrangement is associated with acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL) and other lymphoproliferative diseases.

**Synonyms:** - KMT2A-FOXO3 Fusion Gene - KMT2A::FOXO3 Fusion Gene - MLL-FKHRL1 Fusion Gene - MLL-FOXO3 Fusion Gene - MLL/FKHRL1 Fusion Gene - MLL/FOXO3 Fusion Gene