Allogeneic Anti-HER2 CAR-NK Cells AB-201

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of allogeneic, off-the-shelf (OTS), natural killer (NK) cells derived from cord blood (CB), ex vivo expanded and genetically modified to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human epidermal growth factor receptor 2 (HER2; ErbB2; HER-2), with potential immunomodulating and antineoplastic activities. Upon administration, allogeneic anti-HER2 CAR-NK cells AB-201 recognize, bind to and induce selective cytotoxicity in HER2-expressing tumor cells. HER2 is overexpressed in a variety of cancer cell types and is associated with increased tumor cell proliferation.

**Synonyms:** - AB 201 - AB-201 - AB201 - Allogeneic Anti-HER2 CAR-NKs AB-201 - Allogeneic Anti-HER2 CAR-Natural Killer Cells AB-201