Poly [ADP-Ribose] Polymerase Protein Family

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** A family of glycosyltransferases that catalyzes both the transfer of an adenosine diphosphate (ADP)-ribosyl group of oxidized nicotinamide adenine dinucleotide (NAD(+)) to an acceptor carboxyl group in protein substrates and continued transfer of ADP-ribosyl groups to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. This process (poly-ADP-ribosylation) is involved in a number of cellular processes, including DNA repair, genomic stability and the regulation of programmed cell death.

**Synonyms:** - NAD(+) ADP-Ribosyltransferase - PARP - PARP Family - Poly (ADP-Ribose) Polymerase - Poly [ADP-Ribose] Polymerase - Poly [ADP-Ribose] Polymerase Family - Poly(ADP-Ribose)Polymerase - Poly(Adenosine Diphosphate Ribose) Polymerase