APH1A wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human APH1A wild-type allele is located in the vicinity of 1q21.2 and is approximately 4 kb in length. This allele, which encodes gamma-secretase subunit APH-1A protein, is involved in the stabilization of gamma-secretases complexes. Polymorphisms in the promoter region of this gene may be associated with an increased risk for sporadic Alzheimer's disease.

**Synonyms:** - 6530402N02Rik - APH-1 - APH-1A - APH1A Gamma Secretase Subunit Gene - Anterior Pharynx Defective 1 Homolog A (C. elegans) Gene - Anterior Pharynx Defective 1 Homolog A Gene - Anterior Pharynx Defective 1, C. elegans, Homolog of, A Gene - Aph-1 Homolog A, Gamma-Secretase Subunit wt Allele - Aph-1alpha - Aph1 Homolog A, Gamma-Secretase Subunit Gene - CGI-78 - PSF - UNQ579/PRO1141