Lipid Nanoparticle Encapsulating hAQP1 Circular RNA RXRG001

**Semantic type:** Pharmacologic Substance

**Definition:** A formulation consisting of lipid nanoparticles (LNPs) encapsulating circular RNA (circRNA) encoding human aquaporin-1 (hAQP1), with potential saliva enhancing activity. Upon intraductal administration of LNP encapsulating hAQP1 circRNA RXRG001 to parotid gland(s), the LNP binds to the plasma membrane and releases the circRNA into the cell. The circRNA is then translated to produce hAQP1, which restores water permeability of the cell and increases saliva production. This may alleviate dry mouth symptoms. hAQP1, a water channel protein, is one of several highly conserved water channel proteins that mediates water permeability in cells of water-transporting tissues.

**Synonyms:** - LNP Encapsulating hAQP1 circRNA RXRG001 - Lipid Nanoparticle Encapsulating Human Aquaporin-1 Circular RNA RXRG001 - RXRG 001 - RXRG-001 - RXRG001