Anti-EGFR/c-Met/c-Met Trispecific Antibody BG-T187

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A trispecific antibody targeting epidermal growth factor receptor (EGFR) and two different epitopes of hepatocyte growth factor receptor (HGFR; c-Met), with potential antineoplastic activity. Upon administration, anti-EGFR/c-Met/c-Met trispecific antibody BG-T187 simultaneously targets and binds to the extracellular domain of both EGFR and two different epitopes of c-Met expressed on tumor cells, thereby preventing receptor phosphorylation and activation of both EGFR- and c-Met-mediated signaling pathways. EGFR and c-Met, both upregulated or mutated in a variety of tumor cell types, play key roles in tumor cell proliferation.

**Synonyms:** - Anti-EGFR x c-MET x c-MET Trispecific Antibody BG-T187 - BG T187 - BG-T187 - BGT187 - EGFR x MET TsAb BG-T187 - EGFR x cMET x cMET Trispecific Antibody BG-T187 - EGFR/cMET/cMET Trispecific Antibody BG-T187 - EGFRxMET Trispecific Antibody BG-T187