TPP1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human TPP1 wild-type allele is located in the vicinity of 11p15.4 and is approximately 7 kb in length. This allele, which encodes tripeptidyl-peptidase 1 protein, plays a role in lysosomal degradation of proteins. Mutations in the gene are associated with neuronal ceroid lipofuscinosis 2 and autosomal recessive spinocerebellar ataxia 7.

**Synonyms:** - CLN2 - Cell Growth-Inhibiting Gene 1 Gene - Ceroid-Lipofuscinosis, Neuronal 2, Late Infantile (Jansky-Bielschowsky Disease) Gene - GIG1 - Growth-Inhibiting Protein 1 Gene - LPIC - Lysosomal Pepstatin Insensitive Protease Gene - Lysosomal Pepstatin-Insensitive Carboxypeptidase Gene - SCAR7 - Spinocerebellar Ataxia, Autosomal Recessive 7 Gene - TPP I - TPP-1 - Tripeptidyl Peptidase 1 wt Allele - Tripeptidyl Peptidase I Gene