Activating KDR Gene Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the nucleotide sequence of the KDR gene that results in constitutive activation of vascular endothelial growth factor receptor 2 protein and its downstream signaling pathways.

**Synonyms:** - Activating CD309 Gene Mutation - Activating FLK1 Gene Mutation - Activating Kinase Insert Domain Receptor Gene Mutation - Activating VEGFR-2 Gene Mutation - Activating VEGFR2 Gene Mutation - Activating Vascular Endothelial Growth Factor Receptor 2 Gene Mutation - KDR Activating Gene Mutation - KDR Activating Mutation