LEUTX wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human LEUTX wild-type allele is located in the vicinity of 19q13.2 and is approximately 10 kb in length. This allele, which encodes paired-like homeodomain transcription factor LEUTX protein, plays a role in the transition from maternal to zygotic genome transcription during embryogenesis. Rearrangements involving this gene and the CIC gene are associated with angiosarcoma, anaplastic ganglioglioma, anaplastic astrocytoma with epithelioid glioblastoma multiforme (GBM) features and CIC-rearranged sarcomas.

**Synonyms:** - Arginine-Fifty Homeobox-Like Pseudogene Gene - Leucine Twenty Homeobox wt Allele - Leucine-Twenty Homeobox Gene - Putative Leucine-Twenty Homeobox Gene