Uroporphyrinogen-III Synthase

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** Uroporphyrinogen-III synthase (265 aa, ~29 kDa) is encoded by the human UROS gene. This protein plays a role in cyclization of hydroxymethylbilane yielding the macrocyclic porphyrin precursor uroporphyrinogen III.

**Synonyms:** - EC 4.2.1.75 - Hydroxymethylbilane Hydrolyase - Hydroxymethylbilane Hydrolyase [Cyclizing] - UROIIIS - UROS - Uroporphyrinogen III Synthase - Uroporphyrinogen-III Cosynthase