Head and Neck Adamantinoma-Like Ewing Sarcoma

**Semantic type:** Neoplastic Process

**Definition:** An exceedingly rare variant of Ewing sarcoma with epithelial differentiation that resembles carcinoma and arises from the head and neck. Morphologically, it is characterized by the presence of nests of basaloid cells, tumor cell palisading, myxoid or hyalinized stroma, focal keratin pearl formation, and high-grade features with minimal pleomorphism. It most often arises from the salivary glands, thyroid gland, and sinonasal tract.

**Synonyms:** - Head and Neck ALES