Anti-CCR8 Monoclonal Antibody ABBV-514

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** An afucosylated monoclonal antibody directed against human C-C motif chemokine receptor 8 (CCR8), with potential immunomodulating and antineoplastic activities. Upon administration, anti-CCR8 monoclonal antibody ABBV-514 targets and binds to CCR8 on CCR8-positive, immunosuppressive tumor-infiltrating T regulatory (TITR) cells in the tumor microenvironment (TME). This depletes CCR8-positive TITR cells via antibody-dependent cell-mediated cytotoxicity (ADCC), which may reverse the suppression of CD8+ effector T-cells and reactivate antitumor immune responses. CCR8 is specifically expressed by TITR cells in multiple types of cancer and plays a key role in immunosuppression.

**Synonyms:** - ABBV 514 - ABBV-514 - ABBV514 - Anti-C-C Motif Chemokine Receptor 8 Monoclonal Antibody ABBV-514 - Anti-C-C-chemokine Receptor 8 Monoclonal Antibody ABBV-514