Selatinib

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable dual inhibitor of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (ErbB-2 or HER-2), and an analog of the quinazoline lapatinib, with potential antineoplastic activity. Upon administration, selatinib reversibly blocks phosphorylation of both EGFR and ErbB2, thereby suppressing tumor growth in EGFR/ErbB-2-overexpressing tumor cells. The tyrosine kinases EGFR and ErbB2 have been implicated in the growth of various tumor types.

**Synonyms:** - 4-Quinazolinamine, N-(3-chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfinyl)ethyl)amino)methyl)-2-furanyl)- - L 2 - L-2 - L2 - SELATINIB