DNA-(Apurinic or Apyrimidinic Site) Lyase

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** DNA-(apurinic or apyrimidinic site) lyase (318 aa, ~36 kDa) is encoded by the human APEX1 gene. This protein plays a role in both DNA repair and the regulation of transcription.

**Synonyms:** - AP Endonuclease 1 - AP Endonuclease Class I - AP Lyase - APE - APE-1 - APE1 - APEN - APEX - APEX Nuclease - APEX Nuclease (Multifunctional DNA Repair Enzyme) - APEX1 - APX - Apurinic/Apyrimidinic (Abasic) Endonuclease - Apurinic/Apyrimidinic Endonuclease 1 - Apurinic/Apyrimidinic Exonuclease - Deoxyribonuclease (Apurinic or Apyrimidinic) - EC 3.1.-.- - EC 4.2.99.18 - HAP1 - Multifunctional DNA Repair Enzyme - REF-1 - REF1 - Redox Factor-1