Susceptibility to Multiple System Atrophy-1

**Semantic type:** Disease or Syndrome

**Definition:** A heritable condition caused by mutation(s) in the COQ2 gene encoding 4-hydroxybenzoate polyprenyltransferase, mitochondrial. It is a progressive neurodegenerative disorder affecting both the central and peripheral nervous system. It is clinically and pathologically similar to Lewy body dementia and Parkinson disease.

**Synonyms:** - MSA1