Autologous Anti-FGFR4 CAR T-cells

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) targeting human fibroblast growth factor receptor 4 (FGFR4), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-FGFR4 CAR T-cells recognize and induce selective toxicity in FGFR4-expressing tumor cells. FGFR4, a receptor tyrosine kinase, is involved in angiogenesis and in the proliferation, differentiation, and survival of tumor cells.

**Synonyms:** - Autologous Anti-FGFR4 CAR-T Cells - Autologous FGFR4-CAR T Cells