Ad5-encoding IFNg SP-002

**Semantic type:** Pharmacologic Substance|Virus

**Definition:** A replication deficient adenovirus type 5 (Ad5) vector encoding for the cytokine human interferon gamma (IFNg; IFN-gamma), with potential antineoplastic and immunomodulating activities. Upon intratumoral administration, Ad5-encoding IFNg SP-002 expresses human IFNg, which binds to and activates the cell-surface IFN-gamma receptor and may stimulate an antiproliferative natural killer (NK) cell response against tumor cells and induce tumor cell apoptosis.

**Synonyms:** - Adenoviral Vector Ad5-hIFNg SP-002 - Adenovirus-5 Vector-encoding Human Interferon Gamma SP-002 - SP 002 - SP-002 - SP002