Dihydrofolate Reductase Inhibitor

**Semantic type:** Chemical Viewed Functionally

**Definition:** Any substance that inhibits dihydrofolate reductase, an enzyme that catalyzes the conversion of dihydrofolate to tetrahydrofolate, an essential reaction for de novo glycine and purine synthesis. Inhibition of dihydrofolate reductase interferes with DNA and protein synthesis.

**Synonyms:** - DHFR Inhibitor