EIF2B3 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human EIF2B3 wild-type allele is located in the vicinity of 1p34.1 and is approximately 136 kb in length. This allele, which encodes translation initiation factor eIF2B subunit gamma protein, plays a role in guanyl-nucleotide exchange activity that regulates translation initiation. Mutations in the gene are associated with leukoencephalopathy with vanishing white matter 3, with or without ovarian failure.

**Synonyms:** - EIF-2B - EIF-2B GDP-GTP Exchange Factor Subunit Gamma Gene - EIF2Bgamma - Eukaryotic Translation Initiation Factor 2B Subunit Gamma wt Allele - Eukaryotic Translation Initiation Factor 2B, Gamma Gene - Eukaryotic Translation Initiation Factor 2B, Subunit 3 (Gamma, 58kD) Gene - Eukaryotic Translation Initiation Factor 2B, Subunit 3 Gamma, 58kDa Gene - Eukaryotic Translation Initiation Factor 2B, Subunit 3 Gene - Translation Initiation Factor EIF-2B Subunit Gamma Gene - VWM3