Anti-GARP Chimeric Antigen Receptor-T Cells

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) and transforming growth factor beta (TGFbeta) activator glycoprotein A repetitions predominant (GARP; leucine-rich repeat-containing protein 32; LRRC32), with potential antineoplastic activity. Upon administration, anti-GARP CAR-T cells recognize, bind to and kill GARP-expressing tumor cells. GARP is widely expressed by a variety of human cancer cells compared with normal, healthy cells.

**Synonyms:** - Anti-GARP CAR T Cells - Anti-GARP CAR T-cells - Anti-GARP CAR-T Cells