ARHGEF3 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human ARHGEF3 wild-type allele is located in the vicinity of 3p14.3 and is approximately 352 kb in length. This allele, which encodes Rho guanine nucleotide exchange factor 3, is involved in the regulation of RhoA and RhoB GTPase activities. Variation in the gene may affect bone mineral density and may be associated with postmenopausal osteoporosis.

**Synonyms:** - DKFZP434F2429 - Exchange Factor Found in Platelets and Leukemic and Neuronal Tissues, XPLN Gene - GEF3 - Rho Guanine Nucleotide Exchange Factor (GEF) 3 Gene - Rho Guanine Nucleotide Exchange Factor 3 wt Allele - STA3 - XPLN