Epitinib

**Semantic type:** Pharmacologic Substance

**Definition:** An orally available epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. Upon administration, epitinib inhibits the activity of EGFR, thereby preventing EGFR-mediated signaling. This may lead to induction of cell death and inhibition of tumor growth in EGFR-overexpressing tumor cells. EGFR is a receptor tyrosine kinase (RTK) that is overexpressed in certain tumor types and plays a key role in tumor cell proliferation and vascularization.

**Synonyms:** - 4-Ethyl-N-(4-((3-ethynylphenyl)amino)-7-methoxy-6-quinazolinyl)-1-piperazinecarboxamide - EPITINIB - HMPL 813 Base Form - HMPL-813 Base Form - HMPL813 Base Form