Cefotiam Hexetil

**Semantic type:** Antibiotic|Pharmacologic Substance

**Definition:** The ester prodrug of cefotiam, a semi-synthetic, beta-lactam cephalosporin antibiotic, with antibacterial activity. After administration of cefotiam hexetil the ester bond is cleaved, releasing active cefotiam. Cefotiam binds to penicillin-binding proteins (PBPs), transpeptidases that are responsible for crosslinking of peptidoglycan. By preventing crosslinking of peptidoglycan, cell wall integrity is lost and cell wall synthesis is halted.

**Synonyms:** - 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)acetyl)amino)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-,1-(((cyclohexyloxy)carbonyl)oxy)ethyl Ester, (6R,7R)- - CEFOTIAM HEXETIL - CTM-HE - Cefotiam Hexetil Ester