Primary Package Filling

**Semantic type:** Activity

**Definition:** Filling operating principles involve several associated subprinciples. The primary package can be precleaned to remove particulates or other materials by the use of ionized air, vacuum, or inversion. A holding vessel equipped with an auger, gravity, or pressure material feeding system should be used. The vessel may or may not be able to control temperature and/or agitation. Actual filling of the dosage form into primary containers can involve a metering system based on an auger, gear, orifice, peristaltic, or piston pump. A head-space blanketing system can also be used.

**Synonyms:** - Filling