Androgen Receptor Degrader CC1083610

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable androgen receptor (AR) degrader, with potential antineoplastic activity. Upon oral administration, AR degrader CC1083610 causes degradation of AR, prevents AR-mediated signaling and inhibits the proliferation of AR-overexpressing tumor cells. AR plays a key role in tumor cell proliferation in castration-resistant prostate cancer (CRPC). CC1083610 is the R,S diastereomer of its R,R diastereomer CC1083611 (BMS-986409), and gridegalutamide is a 50:50 mixture of CC1083610 and CC1083611.

**Synonyms:** - AR Degrader CC1083610 - BMS 986410 - BMS-986410 - BMS986410 - CC 1083610 - CC-1083610 - CC1083610