Sorafenib Tosylate

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** The tosylate salt of sorafenib, a synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis.

**Synonyms:** - 4-(4-(3-(4-Chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxyllic Acid Methyamide-4-methylbenzenesulfonate Tosylate - BAY 43-9006 Tosylate - BAY 54 9085 - BAY 54-9085 - BAY 549085 - BAY-54-9085 - BAY549085 - Nexavar - Nexavar - SORAFENIB TOSYLATE - sorafenib - sorafenib tosylate