KLK1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human KLK1 wild-type allele is located in the vicinity of 19q13.33 and is approximately 5 kb in length. This allele, which encodes kallikrein-1 protein, plays a role in the conversion of kininogen-1 to lysyl-bradykinin. Loss of function mutations in the gene are associated with tissue kallikrein deficiency.

**Synonyms:** - Glandular Kallikrein 1 Gene - KLKR - Kallikrein 1 wt Allele - Kallikrein Serine Protease 1 Gene - Kallikrein, Tissue Gene - Klk6 - hK1