Autologous Anti-CCR4 CAR-4-1BB-CD3zeta-expressing T-cells

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) targeting C-C chemokine receptor 4 (CCR4) and linked to the intracellular signaling domains of 4-1BB (CD137) and the zeta chain of the TCR/CD3 complex (TCRzeta; CD247; CD3zeta), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-CCR4 CAR-4-1BB-CD3zeta-expressing T-cells target, bind to and induce selective toxicity in CCR4-expressing tumor cells. CCR4 is a chemokine receptor overexpressed on certain cancer cell types including adult T-cell lymphoma (ATL) and peripheral T-cell lymphoma (PTCL).

**Synonyms:** - Autologous Anti-CCR4 CAR T Cells - Autologous Anti-CCR4 CAR-T Cells - Autologous CCR4-CAR.4-1BB-CD3Zeta-expressing T-cells