Allogeneic TGFBR2 KO Anti-CD70 CAR-transduced NK Cells

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of allogeneic natural killer cells (NKs) that have been engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human cluster of differentiation 70 (CD70) and in which the gene transforming growth factor-beta receptor II (TGFbRII; TGFBR2; TGFBR-2) is deleted, with potential immunostimulating and antineoplastic activities. Upon administration, the allogeneic TGFBR2 KO anti-CD70 CAR-transduced NK cells target, bind to and induce selective cytotoxicity in CD70-expressing tumor cells. CD70, the ligand for the costimulatory receptor CD27, is overexpressed on the surfaces of various cancer cell types. As TGF-beta activation and release leads to NK cell inactivation, deletion of the TGFBR2 gene increases the potency, persistence and efficacy of the NK cells and enhances anti-tumor activity.

**Synonyms:** - ); Allogeneic Transforming Growth Factor-Beta Receptor Type 2 Knockout Anti-CD70 CAR NK Cells - Allogeneic TGFBR-2 KO Anti-CD70 CAR NK Cells - Allogeneic TGFBR-2 KO Anti-CD70 CAR NKs - Allogeneic TGFBR2 KO Anti-CD70 CAR NK Cells - Allogeneic TGFBR2 KO Anti-CD70 CAR-NKs - Allogeneic TGFBR2 KO Anti-CD70 CAR-expressing NK Cells - Allogeneic TGFBR2 KO Anti-CD70 CAR-expressing Natural Killer Cells