Autologous Anti-PHOX2B Peptide-centric CAR T-cells

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the paired mesoderm homeobox protein 2B (PHOX2B) peptide-major histocompatibility complex (p-HLA), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-PHOX2B peptide-centric (PC) CAR T-cells specifically recognize and induce selective toxicity in PHOX2B-expressing tumor cells. PHOX2B, a transcription factor that regulates the differentiation of neural crest cells, is overexpressed in neuroblastoma and has limited expression in normal tissue after birth. The PC CAR T-cells recognize PHOX2B tumor peptides across multiple HLA allotypes across the population.

**Synonyms:** - Autologous Anti-PHOX2B PC CAR T-cells - Autologous Anti-PHOX2B PC CAR-T Cells - Autologous Anti-PHOX2B PC-CAR T Cells - PHOX2B PC-CAR T - PHOX2B Peptide-centric Chimeric Antigen Receptor Autologous T Cells