Hereditary Mixed Polyposis Syndrome

**Semantic type:** Disease or Syndrome

**Definition:** A rare autosomal dominant colorectal neoplasm predisposition syndrome caused by duplications in the regulatory region upstream of the GREM1 gene. It is characterized by the development of colorectal polyps of different histologies, individual colorectal polyps that contain components of more than one histological type, and a predisposition to colorectal adenocarcinoma.

**Synonyms:** - HMPS