Differentiation Syndrome, CTCAE

**Semantic type:** Finding

**Definition:** A potentially fatal complication of treatment in certain molecular subgroups of leukemia characterized by fever, rash, dyspnea and/or hypoxia, pulmonary infiltrates, peripheral edema with rapid weight gain, pleuropericardial effusion, acute renal failure, disseminated intravascular coagulation (DIC), bone pain and/or hypotension.

**Synonyms:** - Differentiation syndrome