Immune Effector Cell-Associated Neurotoxicity Syndrome, CTCAE

**Semantic type:** Finding

**Definition:** A disorder characterized by a pathologic process involving the central nervous system following any immune therapy that results in the activation or engagement of endogenous or infused T cells and/or other immune effector cells. Symptoms or signs can be progressive and may include aphasia, altered level of consciousness, impairment of cognitive skills, motor weakness, seizures, and cerebral edema.

**Synonyms:** - Immune effector cell-associated neurotoxicity syndrome