WRN Inhibitor MOMA-341

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable allosteric inhibitor of the Werner syndrome ATP-dependent helicase (WRN), with potential antineoplastic activity. Upon oral administration, WRN inhibitor MOMA-341 allosterically binds to WRN at cysteine 727, and inhibits the activity of WRN. This induces DNA damage, promotes cell cycle arrest and cell death in, and inhibits the growth of susceptible tumor cells, such as ones with high microsatellite instability (MSI-H). WRN, a multifunctional enzyme with both helicase and exonuclease activities, plays a key role in DNA replication and repair. It is overexpressed in a variety of cancer cells.

**Synonyms:** - MOMA 341 - MOMA-341 - MOMA341 - Werner Syndrome ATP-dependent Helicase Inhibitor MOMA-341