Grade 4 Tumor Inflammation-Associated Neurotoxicity, CTCAE

**Semantic type:** Finding

**Definition:** Life-threatening, clinically significant elevated ICP (>20 mmHg) refractory to CSF drainage with no improvement in clinical symptoms in response to CSF drainage, possibly warranting urgent escalation of neurosurgical intervention; clinical signs and symptoms of impending/early herniation; severe medullary dysfunction requiring endotracheal intubation for airway protection and/or mechanical ventilation

**Synonyms:** - Grade 4 Tumor inflammation-associated neurotoxicity