Cannabidiolic Acid

**Semantic type:** Organic Chemical

**Definition:** A naturally occurring cannabinoid produced in the cannabis plant and precursor to cannabidiol (CBD), with potential anti-emetic, analgesic, anxiolytic, antidepressant, anti-inflammatory, and anti-cancer activities. Cannabidiolic acid (CBDA) is converted to CBD through decarboxylation upon heat or light exposure. CBDA may exert its anti-hyperalgesia activity through its effects on vanilloid receptor 1 (TRPV1), which is a key receptor in pain signaling. CBDA activates the 5-HT1A serotonin receptor, which plays a crucial role in regulating mood and anxiety, and controlling nausea. It also inhibits cyclooxygenase-2 (COX-2), thereby reducing the production of pro-inflammatory mediators. In addition, CBDA may activate the RhoA signaling pathway, which controls cell mobility and thereby may inhibit cancer cell migration.

**Synonyms:** - CANNABIDIOLIC ACID - CBDA - Cannabidiolcarboxylic Acid