MAT2A Inhibitor BG-89894

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** An orally bioavailable inhibitor of methionine adenosyltransferase II alpha (MAT2A), with potential antineoplastic activity. Upon oral administration, MAT2A inhibitor BG-89894 targets, binds to and inhibits the activity of MAT2A, a metabolic enzyme responsible for the production of S-adenosyl-L-methionine (SAM), a primary donor of methyl groups in cellular transmethylation reactions that regulate gene expression, cell growth, and differentiation. Inhibition of MAT2A may inhibit proliferation in methylthioadenosine phosphorylase (MTAP)-deleted cancers that rely heavily on SAM synthesis. MAT2A activity is essential in cancer cells deficient in MTAP, a critical enzyme in the methionine salvage pathway, that is deleted in a variety of human cancers.

**Synonyms:** - BG 89894 - BG-89894 - BG89894 - Methionine Adenosyltransferase 2A Inhibitor BG-89894 - SYH 2039 - SYH-2039 - SYH2039