RAP1B wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human RAP1B wild-type allele is located in the vicinity of 12q15 and is approximately 61 kb in length. This allele, which encodes Ras-related protein Rap-1b, is involved in integrin signaling in platelets, vascular lumen maintenance and GTPase activity. Mutations in the gene are associated with thrombocytopenia 11 with multiple congenital anomalies and dysmorphic facies.

**Synonyms:** - DKFZp586H0723 - K-REV - RAL1B - RAP1B, Member of RAS Oncogene Family wt Allele - RAS-Related Protein RAP1B Gene - Ras Family Small GTP Binding Protein RAP1B Gene - Ras-Related Protein 1B Gene - THC11