Anti-c-Met Monoclonal Antibody VERT-002

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A monoclonal antibody directed against human hepatocyte growth factor receptor (HGFR or c-Met), with potential antineoplastic activity. Upon administration, anti-c-Met monoclonal antibody VERT-002 targets and binds to c-Met, and promotes c-Met degradation, thereby preventing the binding of c-Met to its ligand HGF and the subsequent activation of the HGF/c-Met signaling pathway. This may result in cell death in c-Met-expressing tumor cells. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays a key role in cancer cell growth, survival, angiogenesis, invasion, and metastasis.

**Synonyms:** - Anti-c-Met Monoclonal Antibody PFL-002 - PFL 002 - PFL-002 - PFL002 - VERT 002 - VERT-002 - VERT002