Actinium Ac 225 SSTR2-targeted Agent RYZ401

**Semantic type:** Pharmacologic Substance

**Definition:** A radioconjugate consisting of a somatostatin receptor 2 (SSTR2)-targeting moiety labeled with the alpha-emitting radioisotope actinium Ac 225, with potential antineoplastic activity. Upon administration, actinium Ac 225 SSTR2-targeted agent RYZ401 targets and binds to SSTR2 overexpressed on many types of neuroendocrine tumor (NET) cells. Upon binding and internalization, this radioconjugate specifically delivers a cytotoxic dose of alpha radiation to SSTR2-expressing tumor cells. SSTR2 is present in large numbers on NETs and their metastases, while most normal tissues express low levels of SSTRs.

**Synonyms:** - 225Ac SSTR2-targeted Agent RYZ401 - Ac-225 SSTR2-targeted Agent RYZ401 - Actinium Ac 225-labeled SSTR2-targeted Agent RYZ401 - RYZ 401 - RYZ-401 - RYZ401