SSTR2-targeting Non-peptide Drug Conjugate CRN09682

**Semantic type:** Pharmacologic Substance

**Definition:** A non-peptide drug conjugate composed of a non-peptide somatostatin receptor 2 (SSTR2) agonist linked, via a spacer and a cleavable linker, to the auristatin derivative and microtubule-disrupting cytotoxic agent monomethyl auristatin E (MMAE), with potential antineoplastic activity. Upon administration of SSTR2-targeting NDC CRN09682, the SSTR2 agonist targets and binds to SSTR2 overexpressed on many types of neuroendocrine tumor (NET) cells. Upon binding and linker cleavage, MMAE binds to tubulin and inhibits its polymerization, which results in G2/M phase arrest and induces apoptosis in SSTR2-expressing tumor cells. SSTR2 is present in large numbers on NETs and their metastases, while most normal tissues express low levels of SSTRs.

**Synonyms:** - CRN 09682 - CRN-09682 - CRN09682 - SSTR2-targeting MMAE Non-peptide Drug Conjugate CRN09682 - SSTR2-targeting NDC CRN09682