Indium In 111-ETN029

**Semantic type:** Indicator, Reagent, or Diagnostic Aid|Pharmacologic Substance

**Definition:** A radioconjugate consisting of ETN029, a macrocyclic peptide binder of the tumor-associated antigen (TAA) delta-like protein 3 (DLL3), conjugated to the radioisotope indium In 111 (111In), with potential imaging activity. Upon administration of indium In 111-ETN029, ETN029 targets and binds to DLL3 on DLL3-expressing tumor cells. Upon uptake and imaging, DLL3-expressing tumor cells can be visualized. This allows the assessment of DLL3 expression on tumor cells as well as tumor uptake of the agent. DLL3, a Notch pathway protein, is overexpressed on a variety of cancer cell types. It plays a key role in embryonic development and in tumor initiation and proliferation.

**Synonyms:** - 111In-ETN029 - 111In-MC339 - Indium In 111 ETN029 - Indium In 111 MC339 - Indium In 111-MC339 - Indium In 111-labeled ETN029 - Indium In 111-labeled MC339