Actinium Ac 225-ETN029

**Semantic type:** Pharmacologic Substance

**Definition:** A radioconjugate consisting of ETN029, a macrocyclic peptide binder of the tumor-associated antigen (TAA) delta-like protein 3 (DLL3), conjugated to the alpha-emitting radioisotope actinium Ac 225 (225Ac), with potential antineoplastic activity. Upon administration of actinium Ac 225-ETN029, ETN029 targets and binds to DLL3 on DLL3-expressing tumor cells. Upon binding, the radioisotope moiety delivers a cytotoxic dose of alpha radiation to DLL3-expressing tumor cells. DLL3, a Notch pathway protein, is overexpressed on a variety of cancer cell types. It plays a key role in embryonic development and in tumor initiation and proliferation.

**Synonyms:** - 225Ac-ETN029 - 225Ac-MC339 - Actinium Ac 225 ETN029 - Actinium Ac 225 MC339 - Actinium Ac 225-MC339 - Actinium Ac 225-labeled ETN029 - Actinium Ac 225-labeled MC339