SCN1B wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human SCN1B wild-type allele is located in the vicinity of 19q13.11 and is approximately 10 kb in length. This allele, which encodes sodium channel regulatory subunit beta-1 protein, is involved in the regulation of excitable membrane polarization and neuronal migration during brain development. Mutations in the gene are associated with familial atrial fibrillation 13, Brugada syndrome 5, nonspecific cardiac conduction defect, developmental and epileptic encephalopathy 52 and generalized epilepsy with febrile seizures plus, type 1.

**Synonyms:** - ATFB13 - BRGDA5 - DEE52 - EIEE52 - GEFSP1 - Sodium Channel Subunit Beta-1 Gene - Sodium Channel, Voltage Gated, Type I Beta Subunit Gene - Sodium Channel, Voltage-Gated, Type I, Beta Gene - Sodium Channel, Voltage-Gated, Type I, Beta Polypeptide Gene - Sodium Channel, Voltage-Gated, Type I, Beta Subunit 1 Gene - Sodium Channel, Voltage-Gated, Type I, Beta Subunit Gene - Sodium Voltage-Gated Channel Beta Subunit 1 wt Allele - Sodium Voltage-Gated Channel, Beta Subunit 1 Gene