Oncolytic Adenovirus THEO-260

**Semantic type:** Pharmacologic Substance|Virus

**Definition:** An oncolytic adenovirus, with potential antineoplastic and immunomodulating activities. Upon administration, oncolytic adenovirus THEO-260 specifically infects and replicates in cancer cells and cancer-associated fibroblasts (CAFs), without being able to infect and replicate in normal, healthy cells. This induces selective oncolytic virus-mediated cytotoxicity in cancer cells and CAFs, which leads to cancer cell lysis. The released virus particles, in turn, infect and replicate in neighboring tumor cells, thereby further killing tumor cells. Tumor antigens released from the lysed tumor cells also activate the immune system to induce a tumor-specific systemic immune response, thereby inducing a cytotoxic T-lymphocyte (CTL)-mediated immune response and killing nearby non-infected tumor cells.

**Synonyms:** - Oncolytic Virus THEO-260 - THEO 260 - THEO-260 - THEO260