PPOX wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human PPOX wild-type allele is located in the vicinity of 1q23.3 and is approximately 12 kb in length. This allele, which encodes protoporphyrinogen oxidase protein, plays a role in heme biosynthesis. Mutations in the gene are associated with both the heterozygous and homozygous/compound heterozygous types of variegate porphyria.

**Synonyms:** - PPO - Protoporphyrinogen Oxidase wt Allele - VP - VPCO - Variegate Porphyria Gene