ATM Kinase/DNA-PK Inhibitor NB005

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable, small molecule, dual inhibitor of ataxia telangiectasia mutated kinase (ATM) and DNA-dependent protein kinase (DNA-PK), with potential radio-sensitizing and antineoplastic activities. Upon oral administration, ATM kinase/DNA-PK inhibitor NB005 selectively targets, binds to and inhibits the activity of ATM and DNA-PK. This inhibits ATM-mediated signaling, which may prevent DNA damage checkpoint activation, disrupt DNA damage repair and induce tumor cell apoptosis. By disrupting DNA damage repair, this agent may sensitize tumor cells to radiotherapy and increase its anti-tumor activity. In addition, by inhibiting the activity of DNA-PK, NB005 interferes with the non-homologous end joining (NHEJ) process which may prevent the repair of DNA double strand breaks (DSBs) caused by ionizing radiation. This may also increase radiotherapy cytotoxicity leading to enhanced tumor cell death. ATM, a serine/threonine protein kinase upregulated in a variety of cancer cell types, is activated in response to DNA damage and plays a key role in DNA-strand repair. DNA-PK plays a key role in the NHEJ pathway and DSB repair. The enhanced ability of tumor cells to repair DNA damage plays a major role in the resistance of tumor cells to radiotherapy.

**Synonyms:** - Ataxia Telangiectasia Mutated Kinase/DNA-dependent Protein Kinase Inhibitor NB005 - NB 005 - NB-005 - NB005