Phosphorylated DNA Repair Protein RAD50

**Semantic type:** Amino Acid, Peptide, or Protein

**Definition:** A post-translationally modified form of DNA repair protein RAD50, including serine-470, serine-635 and threonine-690. Specifically, phosphorylation of RAD50 at serine-635 by serine-protein kinase ATM promotes cell cycle arrest, initiates DNA repair mechanisms, restarts DNA replication at stalled forks and enhances cell survival.

**Synonyms:** - Phospho-RAD50 - Phosphorylated RAD50